An NFC West clash takes place on 'Thursday Night Football' for the second week in a row with the Los Angeles Rams hosting the San Francisco 49ers to kick off Week 5. These teams are both 3-1, tying them atop the division alongside Seattle, which defeated Arizona on TNF in Week 4. San Francisco was handed its first loss of the year by the Jacksonville Jaguars on Sunday, falling 26-21 at home. Meanwhile, the Rams just handed the Indianapolis Colts their first defeat with a 27-20 victory in Week 4. Brock Purdy's status is uncertain after having a toe injury setback versus the Jags.

Kickoff is at 8:15 p.m. ET from SoFi Stadium in Inglewood, Calif. The Rams have won each of the last three meetings between the teams. The latest 49ers vs. Rams odds have Los Angeles as the 6.5-point favorite.

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