Thursday Night Football in Week 5 brings a marquee NFC West showdown as the San Francisco 49ers travel south to face the Los Angeles Rams at SoFi Stadium. Kickoff is set for 8:15 p.m. ET, and the game will serve as a key measuring stick for both teams as the season begins to take shape. With divisional stakes on the line, bettors and fans alike are watching closely to see whether the 49ers can spring an upset or if the Rams will continue to assert themselves as one of the NFC’s toughest outs.

Oddsmakers currently have the Rams listed as 7-point favorites, with Los Angeles carrying a strong -325 moneyline compared to San Francisco’s +270. The total for the matchup sits at 46.5 points, suggesting expectations of a balanced game with opportunities on both sides of the ball. Data from Dimers

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