Los Angeles Rams quarterback Matthew Stafford (9) throws against the Indianapolis Colts during the second half at SoFi Stadium in Inglewood, California.

The San Francisco 49ers (3-1) are visiting the LA Rams (3-1) Thursday night in a marquee matchup between division rivals. Kickoff from SoFi Stadium in Inglewood, California, is set for 8:15 p.m. ET (Prime Video). Let's analyze BetMGM Sportsbook's NFL odds around the 49ers vs. Rams odds and make our expert NFL picks and predictions for the best bets.

The 49ers suffered their first loss of the season Sunday, a home game against the Jacksonville Jaguars. Despite getting QB Brock Purdy back from a toe injury, the 49ers fell to Jacksonville, 26-21. That dropped the 49ers to 3-1, putting the first blemish on their record. RB Christian McCaffrey was the leading rusher and receiver with 49 yards on the ground and 92 yards receiving on 6 catches with 1 touchdown.

The Rams bounced back from a Week 3 loss to the Philadelphia Eagles by beating the Indianapolis Colts, 27-20, at home. They stormed back after trailing by 7 points in the fourth quarter, scoring the last 14 points in the final minutes to steal a win from the previously unbeaten Colts. QB Matthew Stafford threw for 375 yards and 3 touchdowns, with 170 of those yards going to WR Puka Nacua, who also caught 13 passes and scored once.

The Rams swept the 49ers last season and will be seeking their first 4-game winning streak against San Francisco since 1999-2001.

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49ers at Rams odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Wednesday at 6:48 p.m. ET.

  • Moneyline (ML): 49ers +300 (bet $100 to win $300) | Rams -375 (bet $375 to win $100)
  • Against the spread (ATS): 49ers +7.5 (-115) | Rams -7.5 (-105)
  • Over/Under (O/U): 46.5 (O: -110 | U: -110)

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49ers at Rams key injuries

49ers

  • DE Nick Bosa (knee) injured reserve
  • WR Jauan Jennings (ankle, rib) out
  • TE George Kittle (hamstring) injured reserve
  • WR Ricky Pearsall (knee) out
  • QB Brock Purdy (toe) out

Rams

  • RT Rob Havenstein (ankle) doubtful
  • TE Tyler Higbee (hip) doubtful
  • CB Ahkello Witherspoon (shoulder) injured reserve

49ers at Rams picks and predictions

Prediction

Rams 24, 49ers 20

Moneyline

Anything can happen in a given week, especially in a game between division rivals on a short week. Yes, the Rams are the healthier team and the better group on paper, but by no means are they worth laying the juice at -375 to win outright.

The 49ers had won 9 of 10 games against the Rams before LA went on a 3-game winning streak since the end of the 2023 season, and these teams always tend to play close games; the last 5 have been decided by 1 score. PASS on the ML.

Against the spread

The Rams are a perfect 4-0 ATS in their last 4 games against the 49ers, but all of those were as underdogs. Prior to that, the 49ers were 6-0 ATS in their previous 6 meetings with the Rams, only twice as favorites.

So in the last 10 games between these teams, the favorites have covered just twice, and both times the 49ers were favored by only 1 point. With how close these games often are, and with the line sitting at -7, take the underdog. BET 49ERS +7.5 (-115).

Over/Under

The Rams defense is underrated and has one of the best pass rushes in the NFL. The 49ers can't say the same thing, but their offensive scheme typically gives the Rams trouble.

It's a Thursday night game where both teams could take a bit of time to find their footing on offense. And with the injuries the 49ers have had, they could struggle to create big plays. BET UNDER 46.5 (-105).

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This article originally appeared on Sportsbook Wire: San Francisco 49ers at LA Rams odds, picks and predictions

Reporting by Cameron DaSilva, Sportsbook Wire / Sportsbook Wire

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