Thursday Night Football offers the first October heavyweight clash of NFC West powers. The Los Angeles Rams and San Francisco 49ers enter SoFi Stadium 3-1 overall — and envisioning continuing their division dominance.

Both teams have split the last four division titles, with the Rams walking in the reigning champs. And this Rams team is fresh off watching Puka Nacua make NFL history and taking NFC Offensive Player of the Week .

San Francisco, meanwhile, suddenly looks depleted in the wide receiver room with Jauan Jennings and Ricky Pearsall out . Even quarterback Brock Purdy won't line up on TNF .

Are signs pointing to a dominating Rams victory? Or do the 49ers have enough to go 4-1? Time for some bold predictions on L.A's side.

Nate Landman will hit career-high numbers facin

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