Week 5 of the NFL season gets underway with a matchup of NFC West rivals when the San Francisco 49ers visit the Los Angeles Rams on "Thursday Night Football."

Both teams are 3-1, with the Rams' lone loss coming in Week 3 against the Philadelphia Eagles thanks to a blocked field goal. The 49ers' defeat occurred Sunday to the Jacksonville Jaguars .

Los Angeles won both matchups last season on its way to the division title. Plagued by injuries, San Francisco finished last. For the NFC West crown this season, the Rams (+125) are a slight favorite over the 49ers (+175), who again have been hit by injuries, as Brock Purdy , Jauan Jennings and Ricky Pearsall are all out.

The Rams enter as 4.5-point favorites for Thursday's game. The teams meet again in Week 10 in San Francisco.

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