The two favorites in the NFC West square off in a key divisional showdown when the Los Angeles Rams and San Francisco 49ers collide in the Week 5 Thursday Night Football game at SoFi Stadium in Inglewood, Calif. The Rams and 49ers both enter the game at 3-1 and tied for the lead in the division with the Seahawks . However at DraftKings, Los Angeles is a slight +110 favorite to win the NFC West, slightly ahead of San Francisco (+190) and Seattle (+370).

The 49ers will face the Rams severely shorthanded offensively. Quarterback Brock Purdy , who missed Weeks 2 and 3 with a toe injury, has been ruled out because of that same toe ailment. Backup Mac Jones , who went 2-0 while Purdy was out, will get the start against Los Angeles. In addition, San Francisco's top two wide receivers,

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