After missing two of the San Francisco 49ers ' first four games, starting quarterback Brock Purdy is set to miss Thursday's NFC West tilt against the Los Angeles Rams . He might be out for even more games after that.

Brock Purdy suffers "setback" with turf toe injury

According to NFL insider Ian Rapoport, Purdy suffered some sort of a setback with his turf toe injury in Sunday's loss to the Jacksonville Jaguars , and is now considered to be out on a week-to-week basis.

That means he could miss significant playing time beyond this week and leave the 49ers offense in the hands of backup Mac Jones for the foreseeable future.

From The @NFLonPrime TNF pregame show: #49ers QB Brock Purdy suffered a setback of his turf toe injury against the #Jaguars and is now considered week-to-

See Full Page