Sarah Mullally, the Bishop of London, was announced Friday as Archbishop of Canterbury, the first time a woman has been chosen as the spiritual leader of the Church of England.

In a speech at the Canterbury cathedral, Mullally highlighted the challenges and uncertainty affecting people around the globe, from wars to climate change, and also addressed safeguarding issues facing the Church of England.

"As a church, we have too often failed to recognise or take seriously the misuse of power in all its forms," she told the congregation.

Mullally said the she was committed as archbishop to ensure that the Church continued to listen to survivors, care for the vulnerable, and foster a culture of safety and wellbeing for all.

Mullally, 63, a former chief nursing officer for England, will face serious challenges including divisions over the treatment of women and LGBTQ people.

She will also have to confront concerns that church leaders haven’t done enough to stamp out the sexual abuse scandals that have dogged the church for more than a decade.

Naming a woman to the position is a major milestone for a church that ordained its first female priests in 1994 and its first female bishop in 2015.

Mullally follows 105 men who have led Anglicans worldwide.

British Prime Minister Keir Starmer welcomed the appointment of Mullally to the role and wished her success.

She will replace former archbishop, Justin Welby, who announced his resignation in November after an independent investigation found he failed to tell police about serial physical and sexual abuse by a volunteer at Christian summer camps as soon as he became aware of it.

While the choice of the new archbishop will be made in England and ratified by King Charles III, it will have ramifications around the world.

The Anglican Communion has more than 85 million members spread across 165 countries, including the Episcopal Church in the United States.

While each national church has its own leader, the Archbishop of Canterbury is considered first among equals.

The process for Mullally was an 11-month marathon presided over by a committee of some 20 people chaired by the former director-general of MI5, Britain’s domestic spy agency.

But it’s not the most transparent of processes. There was no published shortlist of candidates, nor an open vote.

It was more a slow process of sounding out various interest groups to figure out which of the current bishops might be able to lead the church forward.