Marwan Fakih, M.D., is associate director of clinical sciences and medical director of the Judy and Bernard Briskin Center for Clinical Research at City of Hope, a hospital and research center in Duarte, California. In this Managed Healthcare Executive K-Cast video series, Fakih discussed the epidemiology and treatment of squamous cell anal carcinoma.

Increasing incidence and HPV vaccination

The incidence of squamous cell anal carcinoma (SCAC) has almost doubled over the past 30 years, Fakih said. The most important risk factor is HPV infection, he said, and immunosuppression in combination with HPV infection “will drive the carcinogenesis process even further.” People who have HIV in addition to HPV have more than a 30-fold increased risk of getting SCAC, according to Fakih. People ta

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