On Thursday, a team of researchers led by Microsoft announced that they had discovered, and possibly patched, what they're terming a biological zero-day—an unrecognized security hole in a system that protects us from biological threats. The system at risk screens purchases of DNA sequences to determine when someone's ordering DNA that encodes a toxin or dangerous virus. But, the researchers argue, it has become increasingly vulnerable to missing a new threat: AI-designed toxins.

How big of a threat is this? To understand, you have to know a bit more about both existing biosurveillance programs and the capabilities of AI-designed proteins.

Catching the bad ones

Biological threats come in a variety of forms. Some are pathogens, such as viruses and bacteria. Others are protein-based toxins

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