Iowa State Cyclones' quarterback Rocco Becht (3) and Iowa State Cyclones' running back Carson Hansen (26) celebrates after score a touchdown against Arizona during the third quarter in the Big-12 conference showdown on Sept. 27, 2025, at Jack Trice Stadium in Ames, Iowa.

Saturday of Week 6 of the college football season sees the Big 12 jump right into the mix with a fun matchup between Iowa State and Cincinnati that raises some intrigue when you peel back the onion.

Iowa State is 5-0, coming off a bye, and is quite a confident bunch under Matt Campbell. The Cyclones are winning games by blowouts, overseas, in Arkansas, and just about every way you can hope.

Cincinnati has started to make some noise after three straight wins to get them to 3-1, with their sole loss coming to Nebraska by a score of 20-17. They get the Cyclones at home and have the chance to send shockwaves through the Big 12.

Stream Iowa State vs. Cincinnati

If you are looking for some betting advice for the matchup, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

Iowa State vs. Cincinnati game odds

All college football odds via BetMGM

  • Spread: Cincinnati -1.5 (-110), Iowa State +1.5 (-110)
  • Money Line: Cincinnati -115, Iowa State -105
  • Over-Under: Over 54.5 (-115), Under 54.5 (-105)

Iowa State vs. Cincinnati prediction, pick:

It can't be often that an undefeated team is ranked in the top 15 and is an underdog, yet that is the case this week as Iowa State is a slight dog to the Bearcats.

Funny enough, I think Matt Campbell is sick enough that this is exactly what he wants. This is the exact fuel that Iowa State runs on, and it works in this one for the Cyclones as they march to 6-0 with another impressive, gutsy win.

Cincinnati has been fine on offense this year, but they haven't been great, and with the way Iowa State is playing defensively, it is going to take a great offense to knock them off. The Bearcats are putting up 39.5 points per game, but that is inflated by 70 against Northwestern State. Drop that, and it's 29.33 points per game.

Iowa State is allowing 14.2 points per game and will use that as the main ingredient in their recipe of success. Iowa State will rely on QB Rocco Becht to open the offense up just enough through the passing game completing the timely, big throw to keep drives alive, while Carson Hansen churns on the ground against a Cincinnati defense allowing 120 rushing yards against Power Four opponents.

Prediction: Iowa State 27, Cincinnati 17

Best Bet: Iowa State Money Line

Iowa State vs. Cincinnati channel, start time, streaming:

Time: 12 p.m. ET

TV Channel: ESPN2

Live Stream: ESPN App

Get more betting analysis and predictions at Sportsbook Wire.

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This article originally appeared on College Sports Wire: Iowa State vs. Cincinnati: Week 6 College Football Betting Odds, Prediction, Pick

Reporting by Riley Donald, College Sports Wire / College Sports Wire

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