Sep 27, 2025; University Park, Pennsylvania, USA; Penn State Nittany Lions head coach James Franklin reacts during the fourth quarter against the Oregon Ducks at Beaver Stadium. Mandatory Credit: James Lang-Imagn Images

The Big Ten shows off its geographic dominance this week in a matchup spanning four time zones across the country when the Penn State Nittany Lions make the trek to Los Angeles to take on UCLA.

Penn State, coming off a heartbreaking loss to Oregon, is trying to right the ship, and if we are being honest, a game against the Bruins could be just what the doctor ordered.

UCLA has fired its head coach, looks like a mess, and is likely just trying to survive the season. This matchup may be two teams from the same conference, but it will look more like two teams from different levels of football.

Stream Penn State vs. UCLA

If you are looking for some betting advice for the matchup, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

Penn State vs. UCLA game odds

All college football odds via BetMGM

  • Spread: Penn State -24.5 (-105), UCLA +24.5 (-115)
  • Money Line: Penn State -5000, UCLA +1400
  • Over-Under: Over 49.5 (-110), Under 49.5 (-110)

Penn State vs. UCLA prediction, pick:

In a way, there is a part of me that feels bad for UCLA having to be the team to draw Penn State after a loss to Oregon, which has only added fuel to the fire around their stereotype of James Franklin losing big games and Drew Allar throwing late-game interceptions.

UCLA gets to bear the brunt of Penn State coming in angry and trying to rid the taste of that game. Expect Penn State to run the ball at will in this one over and over again until the clock hits zero. Even with a running game eating the clock, this one could get ugly in a hurry.

Prediction: Penn State 44, UCLA 7

Best Bet: Penn State -24.5

Penn State vs. UCLA channel, start time, streaming:

Time: 3:30 p.m. ET

TV Channel: CBS

Live Stream: CBS Sports App, Paramount+

Get more betting analysis and predictions at Sportsbook Wire.

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This article originally appeared on College Sports Wire: Penn State vs. UCLA: Week 6 College Football Betting Odds, Prediction, Pick

Reporting by Riley Donald, College Sports Wire / College Sports Wire

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