Sep 27, 2025; Fayetteville, Arkansas, USA; Notre Dame Fighting Irish head coach Marcus Freeman celebrates after a score during the third quarter against the Arkansas Razorbacks at Donald W. Reynolds Razorback Stadium. Notre Dame won 56-13. Mandatory Credit: Nelson Chenault-Imagn Images

A game that was circled preseason, but may have lost some luster after early-season struggles, still has College Football Playoff implications in play for the Boise State Broncos and Notre Dame Fighting Irish when they get underway from South Bend.

Fair or not, Notre Dame, at 2-2, is essentially playing win-or-go-home games from here on out. If they win out, they are going to be mighty tough to snub from the playoffs. One more loss, though, and the Irish can pack it up.

Boise State is 3-1 and, while they don't control their G5 playoff destiny, they can certainly help their case with an upset over the Irish to make some noise.

Stream Notre Dame vs. Boise State

If you are looking for some betting advice for the matchup, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

Notre Dame vs. Boise State game odds

All college football odds via BetMGM

  • Spread: Notre Dame -20.5 (-110), Boise State +20.5 (-110)
  • Money Line: Notre Dame -1400, Boise State +800
  • Over-Under: Over 62.5 (-115), Under 62.5 (-105)

Notre Dame vs. Boise State prediction, pick:

If you want some Saturday afternoon points, this is the matchup to tune into. These teams score in bunches, and there are no signs of it slowing down this week. Notre Dame's four games have averaged a total of 71.75 points. Boise State's games are averaging 63.25 points. So, let's go with the over here.

As far as the pick, the Irish have to win out, and they know that. They dismantled Arkansas on the road last week, 56-13, and are showing signs of life, much like the team did last year, which made a run to the national championship.

CJ Carr is playing great, with 1,091 yards and nine touchdowns, complemented by Jermiyah Love's 341 rushing yards and Jadarian Price's 273 rushing yards. The Irish are just too much to handle for Boise State as they win their third straight.

Prediction: Notre Dame 45, Boise State 23

Best Bet: Over 62.5

Notre Dame vs. Boise State channel, start time, streaming:

Time: 3:30 p.m. ET

TV Channel: NBC

Live Stream: Peacock

Get more betting analysis and predictions at Sportsbook Wire.

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This article originally appeared on College Sports Wire: Notre Dame vs. Boise State: Week 6 College Football Betting Odds, Prediction, Pick

Reporting by Riley Donald, College Sports Wire / College Sports Wire

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