The Week 6 college football odds board is loaded with high-profile matchups that could have potential College Football Playoff implications. Among the notable Week 6 college football betting lines is No. 10 Alabama (-11.5, 56.5) vs. No. 16 Vanderbilt, No. 18 Florida State vs. No. 3 Miami (-4.5, 53.5), No. 9 Texas (-5.5, 42.5) vs. Florida, Boise State vs. No. 21 Notre Dame (-21, 62.5), and No. 11 Texas Tech (-12.5, 51.5) vs. Houston.

How should you make college football picks for those games, and what are the best spread, total and money-line picks to include in college football best bets? Before locking in any Week 6 college football picks, be sure to see the college football betting guide from legendary Vegas handicapper Bruce Marshall .

New users can also target the latest Under

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