The Week 5 NFL schedule is the first with byes, meaning there are fewer contests to make Week 5 NFL bets on than before. That also means you can devote more time, energy and resources to these matchups, which include a number of inter-conference affairs. Jets vs. Cowboys (-1.5), Broncos vs. Eagles (-4.5), Bengals vs. Lions (-10.5) and Chargers vs. Commanders (+2.5) are some of the AFC vs. NFC games to place Week 5 NFL predictions on.

There is just one divisional game on Sunday and it sees the Bills hosting the Patriots (+8) on 'Sunday Night Football.' Some may prefer making Week 5 NFL picks on common matchups like this one, or the rarer non-conference contests could drum up more interest with NFL betting. All of the updated Week 5 NFL lines are listed below, and SportsLine's advanced comp

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