Kansas City Chiefs quarterback Patrick Mahomes (15) calls a play against the Baltimore Ravens at GEHA Field at Arrowhead Stadium in Kansas City, Missouri.

The Kansas City Chiefs (2-2) and Jacksonville Jaguars (3-1) meet at EverBank Stadium in Jacksonville, Florida, for a Sunday Night Football matchup. Kickoff is set for 8:15 p.m. ET (ABC/ESPN). Let's analyze BetMGM Sportsbook's NFL odds around the Chiefs vs. Jaguars odds and make our expert NFL picks and predictions for the best bets.

Kansas City dominated the Baltimore Ravens 37-20 in Week 4 while covering as a 2.5-point underdog as the Over (48.5) cashed. QB Patrick Mahomes had yet another stellar performance, completing 25-of-37 passes with 4 TDs. The Chiefs forced 2 turnovers and held the Ravens to 4-of-14 on third and fourth down in the win.

Jacksonville escaped with a 26-21 win over the San Francisco 49ers while covering as a 3.5-point underdog with the Over (46) hitting. The Jags didn't have their best game against San Fran, losing the total yards and first down battles while also racking up 12 penalties for 90 yards. However, the Jaguars forced 4 turnovers, including a key fumble with under a minute left in the contest to secure the win.

Kansas City Chiefs lead series 10-6 and has won the last 8 meetings, the latest a 17-9 win in 2023.

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Chiefs at Jaguars odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 7:02 p.m. ET.

  • Moneyline (ML): Chiefs -200 (bet $200 to win $100) | Jaguars +165 (bet $100 to win $165)
  • Against the spread (ATS): Chiefs -3.5 (-110) | Jaguars +3.5 (-110)
  • Over/Under (O/U): 45.5 (O: -110 | U: -110)

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Chiefs at Jaguars key injuries

Chiefs

  • CB Kristian Fulton (ankle) questionable
  • DT Omarr Norman-Lott (shoulder) questionable

Jaguars

  • LB Yasir Abdullah (hamstring) out
  • OT Wyatt Milum (knee) questionable
  • DE Travon Walker (wrist) questionable

Chiefs at Jaguars picks and predictions

Prediction

Chiefs 27, Jaguars 21

Moneyline

PASS.

The Chiefs looked better than they have all season in the win over the Ravens, and that win looked to be exactly what the Chiefs needed to remind themselves who they are. This isn't a flawless team, but with how good Mahomes is playing, the Chiefs are winning this game and covering here as -200 favorites.

However, with KC being on the road and considering how solid this Jacksonville team has been, this bet is not worth the risk, so pass and bet on the spread and/or total instead.

Against the spread

CHIEFS -3.5 (-110).

Eventually, Jacksonville will have to pass the ball for a full drive to score, and I do not trust this Jags offense to go get a score when they need one most, which will lead to the Chiefs winning by more than a field goal in this matchup.

Look for Mahomes and this Kansas City passing game to have a lot of success, especially with opening up the passing game via screen plays. On the other side, look for Kansas City's defense to show that it is still in a class above this Jags offense.

Keep in mind Jacksonville is 3-1 ATS this season.

Over/Under

BET OVER 45.5 (-110).

Kansas City struggles to defend the run while Jacksonville is just as bad defending the pass, meaning that both of these offenses will likely see success in the areas of the offense that they are best in. Furthermore, both Kansas City and Jacksonville put up at least 24 points per game, making these both top-15 scoring offenses that are likely to drive up the score.

There is some risk associated with this bet as both the Chiefs and Jags are top 10 scoring defenses in the NFL, but that feels exaggerated for Jacksonville, so the Over is still much safer here.

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This article originally appeared on Sportsbook Wire: Kansas City Chiefs at Jacksonville Jaguars odds, picks and predictions

Reporting by Payton Shanks, Sportsbook Wire / Sportsbook Wire

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