STOCKHOLM — Mary E. Brunkow, Fred Ramsdell and Dr. Shimon Sakaguchi won the Nobel Prize in medicine on Monday for their discoveries concerning peripheral immune tolerance.

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Mary E. Brunkow, Fred Ramsdell, and Dr. Shimon Sakaguchi have won the Nobel Prize in medicine for their work on peripheral immune tolerance

Their discoveries have advanced treatments for cancer and autoimmune diseases and may improve transplant success

The Nobel Assembly announced the award on Monday

Brunkow, 64, is a senior program manager at the Institute for Systems Biology in Seattle. Ramsdell, 64, is a scientific adviser for Sonoma Biotherapeutics in San Francisco. Sakaguchi, 74, is a distinguished professor at the Immunology Frontier Research Center at Osaka University in Japan.

The immu

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