(BPT) - Silicon Valley may be known as one of the original startup hotbeds, but it's not the only region of the country where entrepreneurs and innovators can bring their ideas to life. In fact, the Midwest has risen to the occasion as the up-and-coming startup hub in the U.S.

Within the Midwest, mid-sized and smaller cities are booming in both visibility and opportunity for entrepreneurs. According to the 2025 Best of the Midwest: Startup City Rankings , cities like Ann Arbor, Michigan; Columbus, Ohio; Cincinnati, Ohio; Indianapolis, Indiana; Madison, Wisconsin; and Lincoln/Omaha, Nebraska, are climbing the ranks, driven by university spinouts, targeted funds and local accelerators. ×

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