The San Francisco 49ers will travel to Tampa Bay to take on the Buccaneers in Week Six at Raymond James Stadium. Both teams hold a 4-1 record and lead their respective divisions in the NFC. Tampa Bay will strive for a victory to start 5-1 for just the sixth time in team history. This will mark the 28th all-time regular season meeting and the Bucs will vie for their first win over the visiting 49ers since 2018. The Bucs face the No.1 pass offense in the NFL and a club boasting Christian McCaffrey and Fred Warner, who currently ranks third in the league with 50 tackles. Baker Mayfield is currently one-of-two quarterbacks in the NFL with 10-plus passing touchdowns and one-or-fewer interceptions, alongside Lamar Jackson.

San Francisco 49ers at Tampa Bay Buccaneers

When: Sunday, Oct. 12, 2025

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