NFL Week 6 brings some tough quarterback decisions. The good news? There are plenty of good matchups to exploit and some struggling defenses ready to be picked apart. The bad news? Key injuries have shaken things up. Here's who to start and who to bench at quarterback this week.

Fantasy point totals are calculated by fantasydata.com.

Start 'em Quarterbacks in Fantasy Football Week 6

Baker Mayfield , TB (vs. SF)

Week 5: 379 yards, 2 TDs, 0 INTs (26.7 fantasy points)

Season: 1,283 yards, 10 TDs, 1 INT | Averaging 21.1 fantasy points per game

The Buccaneers quarterback continues his red-hot 2025 campaign after an excellent Week 5 performance in the 38-35 shootout win over Seattle. The man has been on fire all season with 10 touchdowns against just one interception through five weeks

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