Milwaukee Brewers pitcher Freddy Peralta (51) pitches during the first inning of the NL Division Series game against the Chicago Cubs at American Family Field in Milwaukee, Wisconsin.

The Milwaukee Brewers and Chicago Cubs meet for Game 4 of their best-of-5 NL Division Series Thursday at Wrigley Field in Chicago, Illinois. The Brewers lead the series 2-1. First pitch is scheduled for 9:08 p.m. ET (TBS). Let's analyze BetMGM Sportsbook's MLB odds around the Brewers at Cubs odds and make our expert MLB picks and predictions for the best bets.

Regular-season series: Cubs won 7-6

The Cubs kept their season alive with a 4-3 victory in Game 3 at Wrigley Field Wednesday as the Over (6.5) cashed. Brewers 1B Jake Bauers went 2-for-4 with a homer and 2 RBIs, and he was the only Milwaukee player with a multi-hit effort. The Brewers finished with 7 hits, with DH Christian Yelich went 1-for-5 with a double and a run scored, while OF Jackson Chourio ended up 1-for-4 with a double.

The Cubs posted 8 total hits, with 2B Nico Hoerner going 2-for-4 with a run scored, while All-Star DH Kyle Tucker ended up 2-for-3 with a pair of singles, a walk and a run scored. OF Seiya Suzuki had a double in 4 at-bats, while leaving 5 on base. 1B Michael Busch had a solo homer out of the leadoff spot, accounting for the other extra-base hit.

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Brewers at Cubs projected starters

RHP Freddy Peralta vs. LHP Matthew Boyd

Peralta (17-6, 2.70 ERA) made 33 regular-season starts. He posted a 1.08 WHIP, 3.4 BB/9 and 10.4 K/9 in 176 2/3 innings.

  • Last start (Game 1 vs. Cubs): Win, 5 2/3 IP, 2 ER, 4 H (2 solo HR), 3 BB, 9 K in 9-3 win Saturday
  • 2025 road stats (regular season): 8-5, 3.71 ERA (85 IP, 35 ER), 14 HR, 38 BB, 96 K, 1.15 WHIP in 16 starts
  • 2025 road stats at Wrigley Field: 2-0, 2.45 ERA (11 IP, 3 ER), 2 HR, 5 BB, 12 K in 2 starts
  • Career vs. Cubs (regular season): 9-3, 3.21 ERA (98 IP, 35 ER), 11 HR, 51 BB, 131 K, 1.10 WHIP, 12.0 K/9 in 17 starts (22 appearances)

Boyd (14-8, 3.21 ERA) made 31 regular-season starts. He posted a 1.09 WHIP, 2.1 BB/9 and 7.7 K/9 in 179 2/3 innings.

  • Last start (Game 1 vs. Brewers): Loss, 2/3 IP, 6 R (2 ER), 4 H, 1 BB, 1 K in 9-3 loss Saturday
  • 2025 postseason: 0-1, 5.40 ERA (5 IP, 3 ER), 8 H, 0 HR, 2 BB, 3 K in 2 starts
  • 2025 home stats (regular season): 12-1, 2.51 ERA (89 2/3 IP, 25 ER), 11 HR, 14 BB, 79 K, 0.90 WHIP in 15 starts
  • Career vs. Brewers (regular season): 2-2, 9.00 ERA (23 IP, 23 ER), 9 HR, 16 BB, 19 K, 2.00 WHIP, 7.4 K/9 in 5 starts

Brewers at Cubs odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 2:20 p.m. ET.

  • Moneyline (ML): Brewers -120 (bet $120 to win $100) | Cubs +100 (bet $100 to win $100)
  • Run line (RL)/Against the spread (ATS): Brewers -1.5 (+145) | Cubs +1.5 (-175)
  • Over/Under (O/U): 7 (O: -118 | U: -102)

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Brewers at Cubs picks and predictions

Prediction

Brewers 3, Cubs 2

Moneyline

The BREWERS (-120) are a good bet behind Peralta on Thursday, as they look to salt this series away, and advance to the NLCS to await the winner of the Phillies-Dodgers series.

But, first things first. Milwaukee has dropped 4 of the past 5 games at Wrigley Field since Aug. 19, so there is work to be done. Boyd lost just 1 time in 13 decisions on the north side in the regular season. However, he has looked very ordinary in 2 postseason starts, including Game 1 against Peralta in Cream City.

It took these manager's a little time to settle upon the 2 Game 1 starters for this matchup, but Peralta is the clear-cut choice. He won both of his starts in the regular season at Wrigley Field, and will help Milwaukee advance.

Run line/Against the spread

The CUBS +1.5 (-175) are actually not priced out of line if you'd like a little bit of insurance, and you just don't trust Chicago straight up.

Boyd lost just once in the regular season at home, but there is plenty of risk, as he was knocked around in the series opener, although the defense let him down, contributing to a muted start.

Over/Under

UNDER 7 (-102) is a low number, but the winds will be blowing in from center field at a 9-12 MPH clip right into the face of the batters at Wrigley. That should contribute to the Under, as does the fact both teams have solid starting pitching on the bump.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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This article originally appeared on Sportsbook Wire: Milwaukee Brewers at Chicago Cubs odds, picks and predictions

Reporting by Daniel Dobish, Sportsbook Wire / Sportsbook Wire

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