The 14th-ranked Missouri Tigers will get their first true test of the 2025 college football season when they host the No. 8 Alabama Crimson Tide on Saturday. Mizzou (5-0, 1-0 SEC) has yet to face a ranked team and has played just two Power Conference opponents, as the Tigers defeated UMass, 42-6, in their previous game before a bye last week. Meanwhile, Alabama (4-1, 2-0) has looked like a typical Tide team since losing its opener to Florida State. The Tide are coming off back-to-back wins over ranked SEC teams in Vanderbilt and Georgia.

Kickoff is at noon ET from Memorial Stadium in Columbia, Mo. The Crimson Tide are 3-point favorites in the latest Missouri vs. Alabama odds, after opening as 6.5-point favorites. The over/under for total points scored is 51.5 via SportsLine consensus

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