The Colorado Buffaloes (2-4) are set to host the No. 22 Iowa State Cyclones (5-1) in a Big 12 showdown on Saturday. The Buffs are in their third season under head coach Deion Sanders, and enter this matchup looking for their first win in Big 12 play in 2025. CU is looking to bounce back from its 35-21 loss to TCU in its last outing. Iowa State has its sights set on contending in the Big 12 and making a run at a spot in the College Football Playoff. The Cyclones will be looking to rebound from their 38-30 loss to Cincinnati on Oct. 4. Iowa State is 3-2-1, while CU is 3-3 against the spread in 2025.

Kickoff from Folsom Field in Boulder, Colo. is set for 3:30 p.m. ET. The Cyclones are 3-point favorites in the latest Iowa State vs. Colorado odds, while the over/under for total points scored i

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