The 15th-ranked Michigan Wolverines battle the USC Trojans in a key Big Ten matchup on Saturday night. Michigan is coming off a 24-10 win over Wisconsin last week, while USC is coming off a 34-32 loss at Illinois on Sept. 27. The Wolverines (4-1, 2-0 Big Ten), who are tied for first in the conference, are 1-1 on the road this season. The Trojans (4-1, 2-1 Big Ten), who are tied for fifth, are 3-0 on their home field in 2025.

Kickoff from Los Angeles Memorial Coliseum is at 7:30 p.m. ET. USC leads the all-time series 6-5. The Trojans are 2.5-point favorites in the latest Michigan vs. USC odds, while the over/under for total points scored is 56.5 via SportsLine consensus. Before making any USC vs. Michigan picks, check out the college football predictions from the SportsLine Projectio

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