The Tampa Bay Buccaneers (4-1) will host the San Francisco 49ers (4-1) in an NFL Week 6 NFC showdown on Paramount+ . Baker Mayfield and the Bucs got back into the win column in Week 5 with a 38-35 win against the Seattle Seahawks. They will host a 49ers team that got a couple of days extra rest after defeating the Los Angeles Rams 26-23 in overtime on Thursday Night Football. The 49ers will not have Brock Purdy (toe) available on Sunday, leaving Mac Jones in line for his fourth appearance.

Kickoff from Raymond James Stadium is set for 4:25 p.m. ET on CBS and Paramount+. Tampa Bay is a 3-point favorite in the latest 49ers vs. Buccaneers odds from SportsLine consensus, while the over/under for total points scored is 47.5. The Buccaneers are -161 money line favorites (risk $161 to win

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