New England Patriots at Tennessee Titans odds, picks and predictions

New England Patriots quarterback Drake Maye (10) throws downfield during the second half against the New Orleans Saints at Caesars Superdome in New Orleans Oct. 12.

The New England Patriots (4-2) and Tennessee Titans (1-5) meet in a Week 7 AFC contest. Kickoff from Nissan Stadium in Nashville is set for 1 p.m. ET (CBS). Let's analyze BetMGM Sportsbook's NFL odds around the Patriots vs. Titans odds and make our expert NFL picks and predictions for the best bets.

The Patriots beat the New Orleans Saints 25-19 Sunday in Week 6, covering as a 3.5-point road favorite as the Under (46) hit. QB Drake Maye had another terrific performance, ending with 261 yards and 3 touchdowns. New England sits atop the AFC East and has ripped off 3 straight wins, scoring 23 or more in each of those contests. It is 4-2 against the spread (ATS) on the year.

The Titans lost 20-10 to the Las Vegas Raiders Sunday, failing to cover as a 5-point road underdog. The Under (41.5) cashed. With just 225 total yards, Tennessee struggled to get much going offensively. This caused the Titans to drop the ax on coach Brian Callahan, who was fired afterwards. Senior offensive assistant and former LA Chargers coach Mike McCoy takes over. Tennessee has tallied 20 or fewer in 5 of 6 games this season. The Titans are led by rookie QB Cam Ward, who has 3 touchdowns and 4 interceptions through 6 games.

Tennessee won 20-17 the last time these teams met (Nov. 3, 2024). However, the Patriots covered as a 3.5-point road underdog as the Under (38.5) hit.

Watch the NFL on Fubo!

Patriots at Titans odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 1:30 p.m. ET.

Moneyline (ML): Patriots -325 (bet $325 to win $100) | Titans +260 (bet $100 to win $260)
Against the spread (ATS): Patriots -7 (-110) | Titans +7 (-110)
Over/Under (O/U): 42.5 (O: -110 | U: -110)

Patriots at Titans key injuries

Patriots

S Jaylinn Hawkins (hamstring) questionable
LB Harold Landry III (ankle) questionable
WR Stefon Diggs (chest) questionable

Titans

LB Dre'Mont Jones (knee) questionable
LB Arden Key (quadricep) out
WR Bryce Oliver (knee) out
WR Calvin Ridley (hamstring) out

Patriots at Titans picks and predictions

Prediction

Patriots 24, Titans 20

Moneyline

PASS.

The Patriots (-325) are too risky to play, especially on the road. However, Ward hasn't shown enough to expect the Titans (+260) to be capable of pulling off the upset.

Avoid this play.

Against the spread

BET TITANS +7 (-110).

The Titans haven't won often this season, but they have scored at least 19 points in both home games. Their defense, after a rough start through their first 4 games, has allowed just 20.5 points per game over their last 2 contests. They are 2-1 against the spread (ATS) as an underdog of 7 or greater.

The Patriots have yet to be a favorite of this margin and have scored more than 25 just twice this season, suggesting it might not score enough to seperate itself by this size of margin. It has won just one game by a two-score margin as well.

Back TITANS +7 (-110).

Over/Under

BET OVER 42.5 (-110).

While the Titans offense has left quite a bit to be desired this season, they are 2-0 O/U at home. Ward has had at least a 74 passer rating in both of those performances (only topping that once in 4 road games). Tennessee should continue to eclipse at least 19 at home.

The Patriots, behind a much-improved Maye, have tallied at least 23 points in 3 straight games and are averaging 27 per game on the road. Their defense has given up at least 19 in all but one battle as well. This is also a revenge game of sorts for Patriots coach Mike Vrabel, who was let go by Tennessee a couple years ago.

Put it all together and take OVER 42.5 (-110).

WIN YOUR FANTASY FOOTBALL LEAGUE! The Huddle has been turning players like you into winners for over 25 years. This season, it's your turn. Custom fantasy football rankings, sleepers and tools are just a click away. Subscribe now!

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow SportsbookWire on Twitter/X and like us on Facebook.

Access more NFL coverage:

This article originally appeared on Sportsbook Wire: New England Patriots at Tennessee Titans odds, picks and predictions

Reporting by Nathan Beighle, Sportsbook Wire / Sportsbook Wire

USA TODAY Network via Reuters Connect