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Johnny Depp is making his big Hollywood return ... booking the starring role in the latest re-imagining of a Charles Dickens holiday classic, TMZ has confirmed.

Source tells us ... Depp is in final negotiations to play the namesake in "Ebenezer: A Christmas Carol" ... which is in the works at Paramount Pictures, and will also star Andrea Riseborough . Getty

This 'Carol' iteration is described as ... "A thrilling ghost story set in Dickens’ London, follows one man’s supernatural journey to face his past, present and future and fight for a second chance."

This is major news ... 'cause this will be Depp's first big-budget studio flick since his fall from grace over the Amber Heard saga. Getty

As you recall ... Johnny and Amber married in 2015 before separating just 15

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