ORCHARD PARK, N.Y. (AP) — Buffalo Bills coach Sean McDermott on Friday ruled out three starters from playing this weekend, including safety Taylor Rapp, who will be placed on injured reserve because of a knee issue.

Also ruled out for Buffalo's game at Carolina on Sunday are defensive tackle DaQuan Jones (calf) and receiver Joshua Palmer (knee/ankle). Jones has missed one game, while Palmer was hurt in the first half of a 24-14 loss at Atlanta on Oct. 13.

Rapp’s injury is related to an issue he’s played through since training camp. He’ll miss a minimum four games, leaving the Bills thin at safety.

Buffalo already is without primary backup Damar Hamlin, who is expected to miss a majority of the season after being placed on IR two weeks ago because of a pectoral injury.

The Bills (4-

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