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Cam Skattebo -- the New York Giants breakout rookie running back who has electrified their offense -- was carted off the field after a big hit seemingly left his ankle facing the wrong way.

The 23-year-old fourth-round pick out of Arizona State University took the field against the Philadelphia Eagles ... and, as he was running over the middle on a passing route, when a ball came his way -- and an Eagles defender dragged him down from behind.

Check out the clip ... the Philly player puts all his weight down on CS -- and his legs get caught underneath him as he hits the turf awkwardly.

Almost immediately, Cam's teammates are waving over the medical staff ... and it's easy to see why at the end of the video -- Skattebo's ankle is seemingly twisted the wrong way. Getty

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