This home is ready for its next chapter.

In Manhattan’s Beekman neighborhood — a quiet cul-de-sac on the East River where literary history lingers in the limestone — an iconic penthouse tied to two of America’s most acclaimed writers has reemerged on the market with a reduced ask.

The duplex atop 444 E. 52nd St., once occupied by F. Scott Fitzgerald and Dorothy Parker — according to the listing — is now available for $4.5 million, down sharply from its $6 million listing earlier this year, The Post has learned.

The price drop marks a rare markdown for a property of such architectural and cultural pedigree.

Spanning the 10th and 11th floors of a 1929 Art Deco cooperative, the residence offers nearly 3,000 square feet of interior space and an additional 1,400-square-foot wraparound terra

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