On Tuesday, in an empty room inside Reid Murdoch Building downtown, former Talking Heads frontman David Byrne stood at a keyboard in front of a small audience. The Oscar, Grammy, Tony and Golden Globe winning artist — currently in Chicago for a stop on his “Who is the Sky” tour — stroked two keys on the piano as he explained his forthcoming “Theater of the Mind” production, opening next spring in Chicago.

“Theater of the Mind,” which Byrne co-created with writer Mala Gaonkar, combines elements of neuroscience, art and storytelling for a walkthrough experience on the first floor of a Chicago office building. It is modeled after a production that Byrne opened in Denver in 2022 and will be part of the Goodman Theatre’s century season, marking yet another show under artistic director Susan Bo

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