Key points

Methamphetamine use, methamphetamine use disorders and overdose: no longer just a West Coast problem.

Synthetic methamphetamine/fentanyl are replacing plant-based cocaine/heroin in highly reinforcing speedballs.

There are no FDA-approved treatments for cocaine or methamphetamine overdose or use disorder.

Methamphetamine use , methamphetamine-related overdoses, and methamphetamine use disorder (MUD) are national problems that cause serious illness and death.. Making matters worse, methamphetamine is frequently taken along with fentanyl. Speedballing (using an opioid depressant with a psychostimulant) is an everyday reality. From January 2021 to June 2024, nearly a third (31.2%) of all overdose deaths involved methamphetamine, and almost three-quarters (73.0%) co-involved op

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