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NFL picks, predictions against the spread Week 10: 49ers jump Rams, Steelers stump Chargers, Ravens bump Vikings

Week 9 in the NFL was a bit nuts with upsets from even the biggest of underdogs, including the Packers falling to the Panthers at Lambeau, and the Steelers handing the Colts only their second loss of the season.

As the schedule moves into November, the second half of the 2025 regular season is bound to have its share of surprises.

Despite the rough, shocking results, here's diving into another fearless forecast with picks and predictions against the spread for the follow-up 14-game slate of Week 10:

(Odds court

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