Microdosing isn’t just about mushrooms any more.

While taking tiny non-psychedelic doses of hallucinogens was once the health craze du jour, small, sub-clinical doses of weight loss drugs have taken over the term “microdosing” in 2025.

Little research has been done on the efficacy of GLP-1 drugs like Ozempic when prescribed in smaller doses, but that hasn’t stopped the craze from catching on. People are turning to microdosed GLP-1s to manage their weight, stave off side effects and to make the medications more affordable on a long term basis.

For telehealth companies cashing in on off-brand formulations of popular weight loss drugs, microdosing is an option they’re eager to pitch. Compounded versions of drugs like Novo Nordisk’s semaglutide (Ozempic, Wegovy) and Eli Lilly’s tirzepatide

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