Running backs remain the heart of fantasy football . In Week 10 of the 2025 season, choosing the right one could be the difference between victory and heartbreak. With bye weeks hitting hard and injuries continuing to shuffle depth charts, fantasy managers are once again faced with tricky lineup decisions .

The Cowboys, Bengals, Titans, and Chiefs are on their bye. This means fantasy football lineups will miss key names like Javonte Williams, Chase Brown, and Isiah Pacheco. Meanwhile, teams like the Browns, Jets, Eagles, and Buccaneers return to action. They bring back names like Breece Hall and Rachaad White. Remember, though, that not all are great options this week.

Ahead of Week 10 of the 2025 NFL Season , it’s time to see which RBs to start and which ones to sit in your fant

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