Rare Dual Diagnosis: Alport Syndrome and Immune Complex-Mediated MPGN Coexist in the Same Patient

Turkey : A recently reported case highlights the unusual coexistence of Alport syndrome and immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) in the same patient—a rare dual glomerular pathology that complicates both diagnosis and management. The case highlights the need for timely renal biopsy and genetic evaluation in patients with progressive glomerular disease and a positive family history of renal involvement.

The case, published in BMC Nephrology by Dr. Seyda Gul Ozcan and colleagues from the Division of Nephrology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey, describes a 42-year-old woman of Balkan origin who presented with persistent proteinuria and hematuria. Despite preserved kidney function at initial presentation, her renal pa