A house fire has claimed four lives including two children in a catastrophe the state's premier says will "send ripples through an entire community".

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Emergency services arrived within five minutes of the blaze erupting before 7am on Thursday in the Queensland town of Emerald, about 270km west of Rockhampton.

Two other people had escaped the fire and were outside the home as neighbours attempted to contain the flames with garden hoses.

A man in his 30s and a teenage girl had been killed along with the two toddlers, Queensland Police Senior Sergeant Peter McFarlane confirmed.

"It's been quite traumatic on emergency services," he said.

The t

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