The San Francisco 49ers and Los Angeles Rams clash for the second time in 2025 on Sunday afternoon at Levi’s Stadium in a critical NFC West matchup. With an undefeated divisional record, a victory for the 49ers would be huge for the team to increase its chances of a division crown. After their loss to the 49ers on Thursday Night Football, the Rams have ripped off three consecutive wins over the Ravens, Jaguars, and Saints, with a bye week in between. The 49ers are 2-2 since the first meeting and fresh off a win over the Giants at MetLife Stadium.

So how can the 49ers pull off another win over their divisional rivals? Let’s look at three matchups to watch for on Sunday.

Can the short passing game work again against the Rams’ defense?

In the first matchup, Mac Jones and the depleted 49ers

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