Oct 31, 2025; Houston, Texas, USA; Memphis Tigers head coach Scott Abell congratulates Memphis Tigers running back Greg Desrosiers Jr. (13) on his touchdown against the Rice Owls in the second half at Rice Stadium. Mandatory Credit: Thomas Shea-Imagn Images

Week after week, the American Conference continues to deliver with big games. This Friday night is another massive contest that will send shockwaves through the confernece as two teams tied atop the standings face off.

The Memphis Tigers (8-1, 4-1 American) are on a tear, beating up teams and scoring points in bunches. This week, they get the chance to host the Tulane Green Wave (6-2, 3-1 American) from Simmons Bank Liberty Stadium, with a spot atop the conference up for grabs.

If you are looking for some betting advice for the matchup, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

Stream Tulane vs. Memphis

Tulane vs. Memphis game odds

All college football odds via BetMGM

  • Spread: Memphis -6.5 (-110), Tulane +6.5 (-110)
  • Money Line: Memphis -235, Tulane +195
  • Over-Under: Over 50.5 (-105), Under 50.5 (-105)

Tulane vs. Memphis prediction, pick:

This matchup rides on the ability of Tulane's run defense to step up and perform much better than it has this year. The Green Wave is giving up 158 rushing yards per game and now takes on one of the best rushing attacks in the American.

Memphis is pounding the rock for over 200 yards per game and has already found the endzone 30 times on the ground. The Tigers carry three running backs with at least 450 rushing yards and six touchdowns. Tulane has to figure out slowing them down, or they are in for a long night.

On the other side, Tulane QB Jake Retzlaff is doing it all for the offense. He has 1,622 passing yards, 513 rushing yards, and 16 total touchdowns. It goes through him. He will have his hands full against a Memphis defense that allows only 60% of passes to be completed.

This game comes down to Memphis' run game, which is getting 173 rushing yards per game in conference play. The Tigers get things rolling on the ground and make Tulane play an unsuccessful game of catch-up.

Prediction: Memphis 31, Tulane 21

Best Bet: Memphis -6.5

Tulane vs. Memphis channel, start time, streaming:

Time: 9 p.m. ET

TV Channel: ESPN

Live Stream: ESPN App

Get more betting analysis and predictions at Sportsbook Wire.

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This article originally appeared on College Sports Wire: Tulane vs. Memphis: Week 11 College Football Betting Odds, Prediction

Reporting by Riley Donald, College Sports Wire / College Sports Wire

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