Familiar matchups abound on the NFL Week 10 schedule as there are half a dozen divisional games you can make Week 10 NFL picks on. The highlight of that slate is Rams vs. 49ers, which has L.A. as the 4.5-point road favorite, per the latest NFL odds. The Niners won, 26-23, when the two met in early October, but the Rams had won the three prior matchups. This is one of five games with a Week 10 NFL spread that favors the road team, with the Browns flipped from road underdogs to favorites (-2.5) against the Jets after New York traded away star defenders Sauce Gardner and Quinnen Williams before the trade deadline on Tuesday.

Other divisional contests include Bills vs. Dolphins (+9.5), Saints vs. Panthers (-5.5) and Texans vs. Jaguars (-1.5), with the Jags now favored with C.J. Stroud (concus

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