Running Back Matchups to Target in Week 10 (2025) - James Cook, Rico Dowdle, Kyren Williams, Kyle Monangai

Thunder Dan's favorite RB matchups to exploit for Week 10 of 2025 - DFS running backs to target on DraftKings and FanDuel. These RB matchups are GPP and cash game opportunities.

There are certain running backs, like Christian McCaffrey , who are matchup-proof because of their massive volume of touches or their heavy usage in the pass game. In CMC's case, it's both, and he's projected to lead the slate in rostership again on Sunday this week.

But we can roster two additional running backs on FanDuel and DraftKings in addition to McCaffrey in our cash game lineups, and we can build some McCaffrey-less lineups for tournaments where we fade him, too. So let's find the best possible matchups for the remaining running backs on the slate (CMC's actually doesn't look all that great on paper).