Scientists have long known that genetics play a powerful role in Alzheimer’s disease, with the apolipoprotein E ( APOE ) gene standing out as the single strongest genetic risk factor. Its three variants (i.e., E2, E3, and E4) affect Alzheimer’s risk in dramatically different ways. The E4 version increases the risk of late-onset Alzheimer’s disease up to 13-fold, while E2 appears to be protective, cutting risk by as much as 99%. A new study published in Nature Neuroscience shows that switching between these variants in adult mice can change disease outcomes, offering insights that could inspire future human therapies.

Why target APOE ?

APOE influences how lipids and lipoproteins are metabolized in the brain and body. Beyond lipid handling, it shapes multiple pathw

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