Notre Dame Fighting Irish quarterback CJ Carr (13) hands off to running back Jeremiyah Love (4) against the Navy Midshipmen during the first half at Notre Dame Stadium in South Bend, Indiana.

The Notre Dame Fighting Irish (7-2) and Pitt Panthers (7-2) meet Saturday at Acrisure Stadium in Pittsburgh, Pennsylvania. Kickoff is scheduled for noon ET (ABC). Let's analyze BetMGM Sportsbook's NCAA football odds around the Notre Dame vs. Pitt odds and make our expert college football picks and predictions for the best bets.

Notre Dame leads the all-time series 50-21-1, with 1 vacated win. The Fighting Irish have won 4 in a row in this series, with the last win by the Panthers coming in 2013 in a 28-21 victory. The last meeting was a 58-7 blowout win in South Bend by the Irish in 2023, covering as a 21-point favorite as the Over (46.5) cashed.

No. 9 Notre Dame belted the Navy Midshipmen 49-10 last Saturday, covering as a 31-point favorite as the Over (54.5) cashed. QB CJ Carr passed for 218 yards and 3 TDs, while RB Jeremiyah Love ran for 94 yards and 2 TDs. WR Malachi Fields finished with 4 grabs for 97 yards.

The Fighting Irish have won 7 in a row after starting out 0-2 straight up (SU), but they're just 2-2-1 ATS in the past 5 games, and 2-1 SU and 1-2 against the spread (ATS) in 3 games on the road. The Under is 4-1 in the past 5 games, but the Over is 2-1 in 3 games on the road.

No. 23 Pitt posted a 35-20 win at the Stanford Cardinal last time out as a 14-point favorite as the Over (52) cashed. The Panthers have won and covered 5 in a row, while the Over is 3-1 in the past 4 outings. Pitt's offense has gone for 30 or more points in each of those victories, and 24 or more points in all 9 games to date. QB Mason Heintschel, a true freshman, has thrown for 3 TDs in each of the past 2 games, and he has completed 64.1% of his passes for 1,547 yards, 12 TDs and 5 INT with 1 rushing score in the past 5 starts.

– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

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Notre Dame at Pitt odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 6:15 p.m. ET.

  • Moneyline (ML): Notre Dame -450 (bet $450 to win $100) | Pitt +350 (bet $100 to win $350)
  • Against the spread: Notre Dame -12.5 (-110) | Pitt +12.5 (-110)
  • Over/Under (O/U): 54.5 (O: -110 | U: -110)

Notre Dame at Pitt picks and predictions

Prediction

Notre Dame 31, Pitt 24

Moneyline

Notre Dame (-450) will cost you 4 1/2 times your potential return, and that's way too much risk for not nearly enough reward. The Fighting Irish can bolster their resume with a win, but Pitt's Heintschel is running hot, and the offense is going to be the biggest test since the Texas A&M Aggies game.

PASS.

Against the spread

PITT +12.5 (-110) is worth a look, catching double digits at home.

The Panthers offense has been tremendous, but the question is whether Pitt can hang with a big dog. The past 5 wins and big-time production has been against Stanford, the NC State Wolfpack, Syracuse Orange, Florida State Seminoles and Boston College Eagles, all 5 teams struggling to attain bowl eligibility, let alone qualify for the College Football Playoffs. This is a huge test for the Panthers. If the number slipped down to 11 or lower, then avoid the home side.

Over/Under

OVER 54.5 (-110) is the lean, but go with a half-unit play at most.

The Over has cashed in 2 in a row, and 3 of the past 4 for Pitt. The Panthers are good for at least 24 points in all 9 games to date, so they're going to get theirs. The Panthers have also coughed up 31 or more points in 4 of the past 7 outings, so the Fighting Irish are going to make noise, too.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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This article originally appeared on Sportsbook Wire: Notre Dame Fighting Irish at Pitt Panthers odds, picks and predictions

Reporting by Daniel Dobish, Sportsbook Wire / Sportsbook Wire

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