Kidney failure reversed without any drugs in mice

A new study published in Cell Metbolism has revealed that scientists at the University of Utah Health have successfully reversed acute kidney injury (AKI) in mice without the use of any medication. Instead, researchers achieved the dramatic recovery by genetically altering how the body processes ceramides — fatty molecules that spike during kidney stress and damage the mitochondria that power kidney cells. The results stunned the research team, who reported that kidney function remained completely normal, and the mitochondria stayed intact even under extreme strain. Acute kidney injury is a sudden loss of kidney function. It often follows major infections such as sepsis or medical procedures like heart surgery. More than half of patients in intensive care units experience it, and