GLENDALE, Ariz. (AP) — Arizona had 488 yards of offense, eclipsing San Francisco by more than 200. Jacoby Brissett set an NFL record for completions, had a career high passing and threw two touchdown passes.

The Cardinals never stood a chance.

Plagued by a record number of penalties and multiple miscues, the Cardinals were thumped 41-22 by the 49ers on Sunday for their second straight blowout loss.

“This like a stain,” said Brissett, who completed 47 of 57 passes. “You try and put baking soda on, you try to put club soda on it, you wash it, try to figure something out.”

The Cardinals (3-7) seemed to have bottomed out in last week’s 44-22 loss at Seattle.

They found new depths of ineptitude against the Niners (7-4).

Brissett threw two interceptions — one when two receivers ran simi

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