Nov 15, 2025; Boston, Massachusetts, USA; UConn Huskies head coach Dan Hurley reacts to the action on the floor during the second half against the BYU Cougars at TD Garden. Mandatory Credit: Eric Canha-Imagn Images

Not every night in November do you get a matcup of two top-five teams that could be a precursor to a Final Four matchup of two national title contenders.

The UConn Huskies (4-0) and their fiery head coach, Danny Hurley, who are off to a hot start this season, welcome the Arizona Wildcats (4-0) to Gampel Pavilion in Storrs, Connecticut.

If you are looking for some betting advice for the matchup, we've got you covered. Here are the latest odds for the game, courtesy of DraftKings.

Arizona vs. UConn game odds

All college basketball odds via DraftKings

  • Spread: UConn -4.5 (-115), Arizona +4.5 (-105)
  • Money Line: UConn -205, Arizona +170
  • Over-Under: Over 156.5 (-110), Under 156.5 (-110)

Arizona vs. UConn prediction, pick:

UConn has been tested just once this year in its most recent contest against BYU, which was an 86-84 win. Arizona has notched wins over Florida and UCLA already, flexing its muscles.

Can UCLA generate enough offense against the Huskies? That's what this game comes down to. UConn is allowing just 62 points per game and holding teams below 27% from deep. Arizona doesn't shoot outside a ton, though. Ranked No. 353 in three-point attempts, the Wildcats are going down low, where they convert 54% of shots.

The matchup of Arizona forward Koa Peat, averaging 16.3 points per game, against UConn's center, Tarris Reed Jr., and forward Alex Karaban will be fantastic viewing. It will also be why the Huskies get a home win. UConn has the horses down low and can get Arizona out of their game just enough.

Prediction: UConn 86, Arizona 82

Best Bet: Over 156.5

Arizona vs. UConn start time, streaming:

Time: 7 p.m. ET

TV Channel: FS1

Live Stream: FOX Sports App

Watch Arizona vs. UConn on FuboTV (Free Trial)

Get more betting analysis and predictions at Sportsbook Wire.

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This article originally appeared on College Sports Wire: Arizona vs. UConn: College basketball betting odds, prediction

Reporting by Riley Donald, College Sports Wire / College Sports Wire

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