Monday night’s matchup between the San Francisco 49ers and Carolina Panthers has massive playoff implications. When the schedule was released, very few would believe the Week 12 matchup would have so much on the line, but that is how close the NFC has been in 2025. A victory for the 49ers would increase their playoff probability from 85% to 91%, but a loss would drop them to 69%. The Panthers’ playoff probability is 19% and a win increases their chances to 33% while a loss drops them to 13%.

Both teams are coming off victories, and the Panthers are an upstart team under head coach Dave Canales. The 49ers are healthy-ish on offense (Brandon Aiyuk aside) and are looking for Brock Purdy and company to help lift the team to wins down the stretch. Monday night should be entertaining at Levi’s

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