Week 12 of the 2025 NFL season kicked off on Thursday with a jaw dropping upset as the Davis Mills-led Houston Texans defeated the Josh Allen-led Buffalo Bills 23-19 in a defensive slugfest .

Yes, Mills (153 yards passing and two touchdowns on 16 of 30 passing) was filling in at quarterback for the injured C.J. Stroud , but the real driver behind Houston's win was the Texans' pass rush sacking Allen a career-high eight times. Pro Bowl edge rushers Danielle Hunter (2.0 sacks) and Will Anderson (2.5 sacks) led the way en route to Allen to taking more than half the amount of sacks he took all of last season.

What other unforeseen things could happen in Week 12's weekend NFL action? Let's take a look with five bold predictions.

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