The top Week 12 defense streamers - fantasy football D/ST pickups, streamers and starts for 2025. Target these fantasy DST streaming options with strong matchups.

With Week 11 in the books, it's time to identify defensive streamers for the Week 12 slate of the regular season.

This week, we will spotlight four defensive units that are available in more than 65% of the fantasy leagues that can push for the top-12 upside this week.

Who should fantasy managers look to target on the waiver wire and plug into their starting lineup? Let's dive in! Be sure to check all of our fantasy football rankings for 2025:

2025 fantasy football rankings

Running back (RB) rankings

Wide receiver (WR) rankings

Tight end (TE) rankings

Quarterback (QB) rankings

FLEX rankings

Defense (D/ST) rankings

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