Two studies to investigate the impact of puberty blockers in young people with gender incongruence have been announced by researchers in the UK after an expert view said gender medicine was “built on shaky foundations” .

Puberty blockers were originally used to treat early onset puberty in children but have also been used off-label in children with gender dysphoria or incongruence.

However, the 2024 Cass review of NHS gender identity services for children and young people found there was “insufficient/inconsistent evidence about the effects of puberty suppression on psychological or psychosocial wellbeing, cognitive development, cardio-metabolic risk or fertility”.

NHS England subsequently announced children with gender dysphoria would no longer receive puberty blockers as routi

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